Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis
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چکیده
منابع مشابه
Pharmacokinetics of gentamicin and kanamycin during hemodialysis.
The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...
متن کاملPharmacokinetics of Gentamicin and Kanamycin During Hemodialysis MICHELE
The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...
متن کاملGentamicin pharmacokinetics and pharmacodynamics during short-daily hemodialysis.
BACKGROUND/AIMS Gentamicin pharmacokinetics have not been described in patients undergoing short-daily hemodialysis (SDHD). The aim of this study is to describe gentamicin pharmacokinetics and dialytic clearance (Cl(dial)) in SDHD patients and simulate gentamicin exposure after six dosing regimens to help guide future dosing. METHODS Six anuric patients undergoing SDHD were enrolled. Patients...
متن کاملInfluence of hemodialysis on gentamicin pharmacokinetics, removal during hemodialysis, and recommended dosing.
BACKGROUND AND OBJECTIVES Aminoglycoside antibiotics are commonly used in chronic kidney disease stage 5 patients. The purpose of this study was to characterize gentamicin pharmacokinetics, dialytic clearance, and removal by hemodialysis and to develop appropriate dosing strategies. Design Setting, Participants, and Measurements: Eight subjects receiving chronic, thrice-weekly hemodialysis with...
متن کاملClinical Pharmacokinetics of Gentamicin in Neonates
Gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. Gentamicin is active against the majority of aerobic gram-negative bacilli such as Pseudomonas, Klebsiella and Escherichia coli. The gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. The monitoring of gentamici...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1974
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.6.6.841